THE ROLE OF NATIVE VITAMIN D TREATMENT IN THE CLINICAL ASSESSMENT OF OSTEOPOROSIS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

The role of native vitamin D treatment in the clinical assessment of osteoporosis in patients with chronic kidney disease

The prevalence of vitamin D deficiency is high in patients with chronic kidney disease (CKD).Vitamin D deficiency is associated with various bone disorders SKATE WHEELS such as osteoporosis by affecting bone mineralization.Current international guidelines recommend vitamin D supplementation in CKD as well as in the general population.However, the e

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RESEARCH OF POWER IMPULSES TRANSFER THROUGH THREADED CONNECTIONS OF THE DRILL-STRING DURING ROTARY-PERCUSSION DRILLING OF PILOT HOLES FOR TRENCHLESS PIPELINE LAYING

The relevance of the research.Pilot wells for horizontal directional drilling can be attributed to slim holes that are widely used in mining, in particular, for detailed exploration and underground development of non-ferrous metal ores, for degassing mine workings of coal mines, as well as in a lot of other industries to limit the diameter of a hol

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Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

Summary: Spliceosome machinery mutations are common early mutations in myeloid malignancies; however, effective targeted therapies against them are still lacking.In the current study, we used an in vitro high-throughput drug screen among four different isogenic cell lines and identified RKI-1447, a Rho-associated protein kinase inhibitor, as select

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